1. This movie is gross. I don't know how you could eat popcorn or something during it. 2. It has some funny moments, but it's no laugh fest. (And it's David Hyde Pierce, not Osmosis Jones, who steals the show as the only really likable character.) It is not funny enough to be a real comedy, but not serious or dramatic enough to pull you in emotionally. It does neither adequately, and suffers for it. 3. The villain in it is kinda cool. 4. It is remarkable that the writers and directors of this film felt it was appropriate to mesh a lot of highly original and creative material (the "metropolis" of a human body, complete down to every nuance of its function and translated into animation) with a main character setup that is now so trite (the fast-talking, annoying inner city cop with a chip on his shoulder who plays by his own rules and doesn't follow procedure, paired unwillingly with the practical straight man or some other stereotypical partner who will get on his nerves.) Chris Rock as the mouthy, wise-cracking cop from the wrong side of the tracks.. Jeez. Enough already. I had more than enough of him in Lethal Weapon 4. And Chris Tucker, too. (Same name, same voice, same routine, same kinds of movies. Talk about annoying, and I am not even certain that they are separate people.) The Lethal Weapon 4/Rush Hour/Rush Hour 2/Bad Company shtick has been done to death. 5. This movie had its moments, but overall it was a disappointment. Score: 5 out of 10.

What a total lump of poopoo this was! You've got to be kidding people! Any positive reviews of this movie are plants or insiders from the movie makers themselves! yuuck! disgusting movie!, not gross digusting but just plain awful!

This movie is simply fun and entertaining to watch. I remembered searching for a fantasy movie which similar to "Fantastic Voyage" and this one really got it all. It is even better this movie can be made alive instead of just cartoon and it will be a really marvelous story to be seen. Thumb up.

Osmosis Jones is a really disgusting and gross cartoon/not cartoon movie. Bill Murray, Chris rock, Brandy, Molly Shannon, and Ron Howard were great. I was also surprised to hear a voice from Kid Rock in the movie. This movie is germy and disgusting, but is a fun kid's movie. I give Osmosis Jones a 7 out of 10! :)

This was an odd directorial choice for the Farrelly Brothers ("Dumb and Dumber," "There's Something About Mary"). It's an animated film (in parts) about the internal workings of a man's body. The man is played by Bill Murray during the "live action" sequences. These are intercut with animated sequences that involve cells and amoebas and organs and so on and so forth voiced by the likes of William Shatner, Chris Rock, Laurence Fishburne, David Hyde Pierce (Niles from "Frasier"), Kid Rock and Ron Howard. The cells are all animated cartoon characters who look, talk and act like humans. They live in the vast metropolis of "Frank" (Murray's character). When he feels sick, the metropolis begins to wither away. Chris Rock voices one of Frank's defending cells who teams up with a special medical pill (swallowed by Frank) to take on Thrax (Fishburne), the maniacal germ causing Frank to feel sick. If you think this sounds really weird, you're right. It is. But it's also very clever and unique. The problem is that the animation is poor, the vocal talents are a bit too self-conscious and the animation is almost too realistic at time - it originally got a PG-13 rating. It's pretty seedy stuff. The live action sequences are okay but Murray looks kind of out of it. Overall I was disappointed because I expected something funnier and cleverer, when in fact the movie dies out really quick and resorts to lame jokes like popping whiteheads on people.

I got this thinking my children would enjoy it... The bit they liked best was when I turned it off half way through. We didn't find it funny at all. The body part jokes were either too corny for me to even raise a smile or way beyond my children's biological knowledge for them to understand. The animation also seemed poor to me. If you're brushing up for a biology exam then I guess you may find the huge list of body parts and functions some use. Other than this I wouldn't recommend it. Avoid !!

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source: Osmosis Jones

I think that this movie was horribly underrated in the UK, and it doesn't get the recognition it deserves. I saw the animated series before the movie, and got interested in watching it, but as I have a phobia of vomit, I was incredibly shocked when I saw Bill Murray throw up all over Molly Shannon with visual and graphic sounds. Still, I plucked up the courage to watch the rest of the movie, which I really enjoyed. However, to this day I have to skip the vomit scene on my DVD. I liked the fact that it was a classic "cop type" story, with a baddie, a love interest, a rookie cop and a partnership too. I thought that David Hyde Pierce played the part of Drix brilliantly and Chris Rock was superb as Osmosis. I also like the fact that the movie teaches kids that it's important to take care of yourself. My friend and I still quote "You gotta get spiffy!" all the time. I also really loved the soundtrack, I went frantic searching for the CD!

The premise of the movie itself is pretty creative and how they made the human into a city is very imaginative idea. However even though the animated world is well done with good characters and live action world is lacking. The acting is pretty bad for the live action parts though, the acting is over the top and does not make the audience feel things as we cannot relate to how the characters are reacting to the scenarios, The animation aged well as this was a movie made in 2001 however the CGI did not and just comes off as sloppy and gross to the audience. The story over all is a bit cliche as it is just another buddy cop movie but the premise overall made it more enjoyable then an average movie.